Laboratory of Cell biology and Cytogenetics
Head of the laboratory
Dr. Ing. Miroslava Požgajová
Department of Genetics and Breeding Biology, SUA in Nitra: Ing. Alica Navrátilová, PhD.
Department of Plant Physiology, SUA in Nitra: Ing. Marek Kovár, PhD.
Comenius University in Bratislava, Department of Genetics
Slovak Academy of Science, Centre of Biosciences SAS, Institute of Animal Biochemistry and Genetics
Max F. Perutz Laboratories in Vienna, Austria
Research aims of the laboratory
- Investigation of the role of toxic elements such as Cd, Ni, and Al, or food-born and environmental contaminants on fundamental processes of all living organisms including cell growth, cell morphology, regulation of chromosome segregation during cell cycle
- Determination of the antioxidant status of the organism upon toxic element treatment and characterization of the possible positive effect of biologically active substances such as ascorbic acid against toxicity of the particular contaminant
- Determination of the cellular defense mechanisms on molecular basis
Schematic draw of the population intoxication by environmental toxicants, such as heavy metals, through the food chain.
ITMS2014+ 313011V336 (Drive4SIFood) – molecular consequences derived from food contamination
ITMS2014+ 313012P694 (Frost) – determination of acrylamide toxicity to living organisms
ITMS2014+ 313011W580 (Uranos) – analyses of the antioxidant capacity of the organism under stress conditions of the environment
APVV-19-0598 – determination of the impact of beta glucan upon contamination of the living environment
Navrátilová, A., Kovár, M. and Požgajová, M., 2021. Ascorbic acid mitigates cadmium-induced stress, and contributes to ionome stabilization in fission yeast. Environmental Science and Pollution Research, 28(12), pp.15380-15393. https://doi.org/10.1007/s11356-020-11480-x
Požgajová, M., Navrátilová, A., Šebová, E., Kovár, M. and Kačániová, M., 2020. Cadmium-Induced Cell Homeostasis Impairment is Suppressed by the Tor1 Deficiency in Fission Yeast. International journal of molecular sciences, 21(21), p.7847. https://doi.org/10.3390/ijms21217847
Pozgajova, M., Navratilova, A., Arvay, J., Duranova, H. and Trakovicka, A., 2020. Impact of cadmium and nickel on ion homeostasis in the yeast Schizosaccharomyces pombe. Journal of Environmental Science and Health, Part B, 55(2), pp.166-173. https://doi.org/10.1080/03601234.2019.1673613
Pozgajova, M. and Duranova, H., 2021. BIOLUMINOMETRIC ASSAY OF CELL ATP DETECTION UNDER STRESS CONDITIONS AND IN THE ASSESSMENT OF CLEANNESS OF THE FOOD PRODUCING COMPANY. Journal of microbiology, biotechnology and food sciences, 10(5), pp.e2584-e2584. https://doi.org/10.15414/jmbfs.2584